Adrenergic & Muscarinic Antibodies in POTS - Dr. Blair Grubb

Dr. Blair Grubb presented findings from his recent study on the role of adrenergic and muscarinic antibodies in POTS. The study found that nearly 90% of POTS patients exhibited elevated levels of autoantibodies, particularly against alpha-1 adrenergic receptors. Additionally, about 50% of these patients also had elevated muscarinic receptor autoantibodies, which could be linked to bowel motility disorders common in POTS. The presence of these antibodies suggests an autoimmune component in the pathophysiology of POTS. However, the study notes that these autoantibodies could be markers of another underlying process rather than the direct cause. Dr. Grubb's ongoing research aims to further elucidate these mechanisms, acknowledging that while these findings are promising, more research is necessary to confirm their clinical significance and the potential for targeted immunotherapy.