2022 Immune Dysfunction in HSD and EDS: Beyond Mast Cell Activation Disease - Dr. Anne Maitland

Dr. Anne L. Maitland's presentation at the 2022 EDS ECHO Summit explores the relationship between immune dysfunction and connective tissue disorders such as Ehlers-Danlos Syndrome (EDS) and Hypermobile Spectrum Disorder. While mast cell activation disease (MCAD) is prevalent in these individuals, the discussion highlights various triggers and responses in mast cells that extend beyond classical allergy pathways. She introduces criteria for diagnosing mast cell activation syndrome (MCAS) and emphasizes the need to identify different phenotypes and underlying triggers, which range from allergic reactions to undiagnosed immune deficiencies. Dr. Maitland also addresses the comorbid presence of such immune deficiencies in individuals with hypermobile joints, suggesting that they may predispose to more generalized hypersensitivity reactions. The talk underscores the importance of a comprehensive diagnostic approach and the potential of both pharmacologic and non-pharmacologic interventions, including novel therapies and traditional methods, to manage these complex conditions.