2021 Lectures: The Pentad Patient: Ilene S Ruhoy, M.D., PhD

In this lecture, Dr. Ilene S Ruhoy discusses the concept of the 'Pentad Patient,' which involves a set of interconnected conditions often seen together, including hypermobility type Ehlers-Danlos Syndrome (EDS), mast cell activation syndrome (MCAS), dysautonomia (such as POTS), small fiber neuropathy, and gastrointestinal dysmotility. Dr. Ruhoy explains that these conditions frequently co-occur due to connective tissue issues, immune system interactions, and other factors. She emphasizes the difficulty in finding specific genetic markers for these conditions, but notes a familial tendency. Various treatment options, such as medications for mast cell stabilization and supportive measures for dysautonomia, are discussed. Dr. Ruhoy stresses the importance of a tailored approach to treatment, taking into account the patient's most debilitating symptoms, and highlights the role of clinical judgment when diagnostic testing yields ambiguous results.