# 13. The role of Mast Cells in complex illness: what they are and how to calm them, with Dr. The...

In this podcast episode, Dr. Theoharis Theoharides, a leading researcher on mast cells, discusses their significant role in complex chronic illnesses. Mast cells, which are distributed throughout the body, can be activated by various stressors, contributing to symptoms seen in conditions like migraines, irritable bowel syndrome, and possibly others categorized under comorbidities. Dr. Theoharides highlights the need for improved diagnostic tools, greater awareness, and integrative treatment strategies, emphasizing lifestyle changes and natural flavonoids for inhibiting mast cell activity. He also mentions challenges in research funding and suggests an integrative, patient-centered approach to treating these conditions. Dr. Theoharides's work at Nova Southeastern University aims to develop strategies to better understand and manage conditions related to mast cell activation. He advocates for a better understanding of mast cells in complex conditions, citing potential intersections with ME/CFS, post-viral syndromes, and other chronic illnesses.